Where can I find Oral and home Ketamine therapies? Contact NOVA Health Recovery in Alexandria, Virginia
Recent clinical trials and metanalysis recognize the efficacy of Ketamine infusions and therapies in the treatment of resistant depression:
At NOVA Health Recovery Ketamine Infusion Center, (Alexandria, Virginia), we have found the incredible effectiveness of ketamine infusions for a rapid relief of depression with a transition to Sublingual, home-based ketamine therapies for follow-up. We have found that doses for infusions between 0.5 mg/kg and 1 mg/kg to provide the best response and that repeated infusions are effective and safe:
Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD) supports the doses of 0.5-1 mg/kg IV
Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression – Ketamine was associated with a rapid antidepressant effect in treatment resistant depression (TRD) that was predictive of a sustained effect. The effect could wear off, on average at 18 days. There was a 70% response rate. Repeated infusions could be used to maintain effect.
Maintenace of ketamine infusions is a way to maintain the durability of depression responses:
Maintenance Ketamine Therapy for Treatment-Resistant Depression Maintenance ketamine treatments may be an effective way of maintaining treatment response in some ketamine responders.
As part of our maintenance between infusions, or to lengthen the period of needing the infusions, we utilize oral and sublingual ketamine. An article recently addressed concept as well:
Sublingual Ketamine has a 30% availability (versus oral ketamine at 20%):
The issue with sublingual ketamine is that the doses used need to be higher, to 1.5 mg/kg dosing ranges, and this can maintain effectiveness of the antidepressant response. A systematic review using oral ketamine recognized its value in treating depression, but many of the studies used lower doses than they should have:
Oral Ketamine for Depression: A Systematic Review In this review, efficacy was seen in 2-4 weeks with oral ketamine and the dosages and frequency of administration were variable (ie, 0.5-7.0 mg/kg 3 times daily to once monthly), with most studies providing dosages of 1-2 mg/kg every 1-3 days.
However, sublingual ketamine used at higher doses (1.5 mg/kg) can also be rapidly effective and can be used to help maintain the response to therapy.
Why is this important? It is cheaper and patients can maintain themselves with fewer infusions. Also, per may studies, symptoms may return around 18 days (about 2 and a half weeks) after the last infusion:
Daily oral ketamine has demonstrated efficacy in decreasing depression and anxiety in hospice care patients as well (at 0.5 mg/kg daily):
Although studies are being conducted regarding different administration routes for ketamine, many centers have used oral and SL ketamine with monthly ketamine infusions with excellent success as a maintenance therapy for depression and bipolar disorder.
Contact NOVA Health Recovery Ketamine Infusion Center if you are interested in ketamine therapies for depression using IV or home-based oral and nasal spray regimens.